Mining Modifier SNPs in Mendelian Disease
Use gnomAD, ClinVar, and AlphaMissense to find SNPs that may soften Mendelian disease severity and build advanced variant analysis skills.
Use gnomAD, ClinVar, and AlphaMissense to find SNPs that may soften Mendelian disease severity and build advanced variant analysis skills.
Build a time-lapse imaging system and quantify yeast colony shape changes with deep learning, statistics, and phenotype mapping.
Build a pupil-tracking pipeline that links smartphone video features to cognitive load and anxiety, then test how well it predicts self-reports.
Track how LED light colors shift fruit fly sleep and activity, then connect the pattern to clock-gene expression data for stronger analysis.
Build a yeast fluorescence reporter, fit Hill curves, and compare dose-response behavior to literature while learning quantitative colorimetry.
Measure phagocytosis in Tetrahymena with smartphone microscopy and compare how stress, caffeine, and β-glucan change uptake rates.
Measure cytoplasmic streaming in plant cells, test temperature and caffeine effects, and build image-based velocity analysis skills.
Analyze mitochondrial heteroplasmy from public genome data and build a simple age-estimation model while learning variant calling and statistics.
Build a drug repurposing pipeline that matches Parkinson’s gene signatures to reversal candidates and tests binding-pocket signals with AlphaFold.
Use public spatial transcriptomics data to find tumor margin gene patterns, build a boundary-cell score, and test invasion links.